Free Access
Issue
Environ. Biosafety Res.
Volume 7, Number 4, October-December 2008
Page(s) 219 - 226
DOI https://doi.org/10.1051/ebr:2008020
Published online 07 October 2008
  • Arcalis E, Marcel S, Altmann F, Kolarich D, Drakakaki G, Fischer R, Christou P, Stoger E (2004) Unexpected deposition patterns of recombinant proteins in post-endoplasmic reticulum compartments of wheat endosperm. Plant Physiol. 136: 3457–3466 [Google Scholar]
  • Boehm R (2007) Bioproduction of therapeutic proteins in the 21st century and the role of plants and plant cells as production platforms. Ann. N. Y. Acad. Sci. 1102: 121–134 [Google Scholar]
  • Bradford MM (1976) A rapid and sensitive method for the quantification of micrograms quantities of protein utilizing the principle of protein dye binding. Anal. Biochem. 72: 248–254 [CrossRef] [PubMed] [Google Scholar]
  • Commandeur U, Twyman M, Fisher R (2003) The biosafety of molecular farming in plants. AgBiotechNet 5: 1–9 [Google Scholar]
  • Drakakaki G, Marcel S, Arcalis E, Altmann F, Gonzalez-Melendi P, Fischer R, Christou P, Stoger E (2006) The intracellular fate of a recombinant protein is tissue dependent. Plant Physiol. 141: 578–586 [Google Scholar]
  • Elbehri A (2005) Biopharming and the food system: examining the potential benefits and risks. Agbioforum 8: 18–25 [Google Scholar]
  • Faye L, Boulaflous A, Benchabane M, Gomord V, Michaud D (2005) Protein modifications in the plant secretory pathway: current status and practical implications in molecular pharming. Vaccine 23: 1770–1778 [CrossRef] [PubMed] [Google Scholar]
  • Floss DM, Falkenburg D, Conrad U (2007) Production of vaccines and therapeutic antibodies for veterinary applications in transgenic plants: an overview. Transgenic res. 16: 315–332 [Google Scholar]
  • Franconi R, Roggero P, Pirazzi P, Arias FJ, Desiderio A, Bitti O, Pashkoulov D, Mattei B, Bracci L, Masenga V, Milne RG, Benvenuto E (1999) Functional expression in bacteria and plants of an scFv antibody fragment against tospoviruses. Immunotechnology 4: 189-201 [Google Scholar]
  • Jurgens G (2004) Membrane traffiking in plants. Annu. Rev. Cell Dev. Biol. 20: 481–504 [Google Scholar]
  • Kermode AR (2006) Plants as factories for the production of biopharmaceutical and bioindustrial proteins: lessons from cell biology. Can. J. Bot. 84: 679–694 [Google Scholar]
  • Komarnytsky S, Borisjuk N, Yakoby N, Garvey A, Raskin I (2006) Cosecretion of protease inhibitor stabilize antibodies produced by plant roots. Plant Physiol. 141: 1185–1193 [Google Scholar]
  • Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680–685 [Google Scholar]
  • Liénard D, Sourrouille C, Gomord V, Faye L (2007) Pharming and transgenic plants. Biotechnol. Annu. Rev. 13: 115–147 [Google Scholar]
  • Lilley AK, Bailey MJ, Cartwright C, Turner SL, Hirsch PR (2006) Life in earth: the impact of GM plants on soil ecology? Trends Biotechnol. 24: 9–14 [Google Scholar]
  • Munro S, Pelham HR (1987) A C-terminal signal prevents secretion of luminal ER proteins. Cell 48: 899–907 [CrossRef] [PubMed] [Google Scholar]
  • Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassay with tobacco tissue cultures. Physiol. Plant. 15: 473–497 [CrossRef] [Google Scholar]
  • Petruccelli S, Otegui MS, Lareu F, Tran Dinh O, Fitchette AC, Circosta A, Rumbo M, Bardor M, Carcamo R, Gomord V, Beachy RN (2006) A KDEL-tagged monoclonal antibody is efficiently retained in the endoplasmic reticulum in leaves, but is both partially secreted and sorted to protein storage vacuoles in seed. Plant Biotechnol. J. 4: 511–527 [Google Scholar]
  • Pujol M, Gavilondo J, Ayala M, Rodrìguez M, Gonzàlez EM, Pèrez L (2007) Fighting cancer with plant-expressed pharmaceuticals. Trends Biotechnol. 25: 455–459 [Google Scholar]
  • Ramessar K, Peremerti A, Gomez-Galera S, Naqvi S, Moralejo M, Munoz P, Capell T, Christou P (2007) Biosafety and risk assessment framework for selectable marker genes in transgenic crop plants: a case of the science not supporting the politics. Transgenic Res. 16: 261–280 [Google Scholar]
  • Sabharwal N, Icoz I, Saxena D, Stotzky G (2007) Release of the recombinant proteins, human serum albumin, beta-glucuronidase, glycoprotein B from human cytomegalovirus, and green fluorescent protein, in root exudates from transgenic tobacco and their effects on microbes and enzymatic activities in soil. Plant Physiol. Biochem. 45: 464–469 [Google Scholar]
  • Saint-Jore-Dupas C, Faye L, Gomord V (2007) From planta to pharma with glycosylation in the toolbox. Trends Biotechnol. 25: 317–323 [Google Scholar]
  • Sanvido O, Romeis J, Bigler F (2007) Ecological impacts of genetically modified crops: ten years of field research and commercial cultivation. Adv. Biochem. Eng. Biotechnol. 107: 235–278 [PubMed] [Google Scholar]
  • Saxena D, Flores S, Stotzky G (2002) Bt toxin is released in root exudates from 12 transgenic corn hybrids representing three transformation events. Soil Biol. Biochem. 34: 133–137 [Google Scholar]
  • Saxena D, Stewart CN, Altosaar I, Shu Q, Stotzky G (2004) Larvicidal Cry proteins from Bacillus thuringensis are released in root exudates of transgenic B. thuringensis corn, potato and rice but not of B. thuringensis canola, cotton and tobacco. Plant Physiol. Biochem. 42: 383–387 [Google Scholar]
  • Sparrow PAC, Irwin JA, Dale PJ, Twyman RM, Ma J-KC (2007) Pharma-Planta: road testing the developing regulatory guidelines for plant-made pharmaceuticals. Transgenic Res. 16: 147–161 [Google Scholar]
  • Spök A (2007) Molecular farming on the rise-GMO regulators still walking a tightrope. Trends Biotechnol. 25: 74–82 [Google Scholar]
  • Streatfield SJ (2007) Approaches to achieve high-level heterologous protein production in plants. Plant Biotechnol. J. 5: 2–15 [Google Scholar]
  • Toubart P, Desiderio A, Salvi G, Cervone F, Daroda L, De Lorenzo G (1992) Cloning and characterization of the gene encoding the endopolygalacturonase-inhibiting protein (PGIP) of Phaseolus vulgaris L. Plant J. 2: 367–373 [PubMed] [Google Scholar]
  • Towbin H, Staehelin T, Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedures and some applications. Proc. Natl. Acad. Sci. USA 76: 4350–4353 [Google Scholar]
  • Twyman RM, Schillberg S, Fischer R (2005) Transgenic plants in the biopharmaceutical market. Expert Opin. Emerg. Drugs 10: 185–218 [CrossRef] [PubMed] [Google Scholar]
  • Van Droogenbroeck B, Cao J, Stadlmann J, Altmann F, Colanesi S, Hillmer S, Robinson DG, Van Lerberge E, Terryn N, van Montagu M, Liang M, Depicker A, De Jaeger G (2007) Aberrant localization and underglycosylation of highly accumulating single-chain Fv-Fc antibodies in transgenic Arabidopsis seeds. Proc. Natl. Acad. Sci. USA 104: 1430–1435 [Google Scholar]
  • van Esse HP, Thomma BPHJ, van't Klooster JW, de Wit PJGM (2006) Affinity-tags are removed from Cladosporium fulvum effector proteins expressed in the tomato leaf apoplast. J. Exp. Bot. 57: 599–608 [Google Scholar]
  • Vitale A, Pedrazzini E (2005) Recombinant pharmaceuticals from plants: the plant endomembrane system as bioreactor. Mol. Interv. 5: 216-225 [Google Scholar]
  • Widmer (2007) Assessing effects of transgenic crops on soil microbial communities. Adv. Biochem. Eng. Biotechnol. 107: 207–234 [Google Scholar]
  • Wolt JD, Karaman S, Wang K (2007) Risk assessment for plant-made pharmaceuticals. CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources 2: 1–9 [Google Scholar]