Free Access
Issue
Environ. Biosafety Res.
Volume 7, Number 4, October-December 2008
Page(s) 219 - 226
DOI https://doi.org/10.1051/ebr:2008020
Published online 07 October 2008
  • Arcalis E, Marcel S, Altmann F, Kolarich D, Drakakaki G, Fischer R, Christou P, Stoger E (2004) Unexpected deposition patterns of recombinant proteins in post-endoplasmic reticulum compartments of wheat endosperm. Plant Physiol. 136: 3457–3466
  • Boehm R (2007) Bioproduction of therapeutic proteins in the 21st century and the role of plants and plant cells as production platforms. Ann. N. Y. Acad. Sci. 1102: 121–134
  • Bradford MM (1976) A rapid and sensitive method for the quantification of micrograms quantities of protein utilizing the principle of protein dye binding. Anal. Biochem. 72: 248–254 [CrossRef] [PubMed]
  • Commandeur U, Twyman M, Fisher R (2003) The biosafety of molecular farming in plants. AgBiotechNet 5: 1–9
  • Drakakaki G, Marcel S, Arcalis E, Altmann F, Gonzalez-Melendi P, Fischer R, Christou P, Stoger E (2006) The intracellular fate of a recombinant protein is tissue dependent. Plant Physiol. 141: 578–586
  • Elbehri A (2005) Biopharming and the food system: examining the potential benefits and risks. Agbioforum 8: 18–25
  • Faye L, Boulaflous A, Benchabane M, Gomord V, Michaud D (2005) Protein modifications in the plant secretory pathway: current status and practical implications in molecular pharming. Vaccine 23: 1770–1778 [CrossRef] [PubMed]
  • Floss DM, Falkenburg D, Conrad U (2007) Production of vaccines and therapeutic antibodies for veterinary applications in transgenic plants: an overview. Transgenic res. 16: 315–332
  • Franconi R, Roggero P, Pirazzi P, Arias FJ, Desiderio A, Bitti O, Pashkoulov D, Mattei B, Bracci L, Masenga V, Milne RG, Benvenuto E (1999) Functional expression in bacteria and plants of an scFv antibody fragment against tospoviruses. Immunotechnology 4: 189-201
  • Jurgens G (2004) Membrane traffiking in plants. Annu. Rev. Cell Dev. Biol. 20: 481–504
  • Kermode AR (2006) Plants as factories for the production of biopharmaceutical and bioindustrial proteins: lessons from cell biology. Can. J. Bot. 84: 679–694
  • Komarnytsky S, Borisjuk N, Yakoby N, Garvey A, Raskin I (2006) Cosecretion of protease inhibitor stabilize antibodies produced by plant roots. Plant Physiol. 141: 1185–1193
  • Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680–685
  • Liénard D, Sourrouille C, Gomord V, Faye L (2007) Pharming and transgenic plants. Biotechnol. Annu. Rev. 13: 115–147
  • Lilley AK, Bailey MJ, Cartwright C, Turner SL, Hirsch PR (2006) Life in earth: the impact of GM plants on soil ecology? Trends Biotechnol. 24: 9–14
  • Munro S, Pelham HR (1987) A C-terminal signal prevents secretion of luminal ER proteins. Cell 48: 899–907 [CrossRef] [PubMed]
  • Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassay with tobacco tissue cultures. Physiol. Plant. 15: 473–497 [CrossRef]
  • Petruccelli S, Otegui MS, Lareu F, Tran Dinh O, Fitchette AC, Circosta A, Rumbo M, Bardor M, Carcamo R, Gomord V, Beachy RN (2006) A KDEL-tagged monoclonal antibody is efficiently retained in the endoplasmic reticulum in leaves, but is both partially secreted and sorted to protein storage vacuoles in seed. Plant Biotechnol. J. 4: 511–527
  • Pujol M, Gavilondo J, Ayala M, Rodrìguez M, Gonzàlez EM, Pèrez L (2007) Fighting cancer with plant-expressed pharmaceuticals. Trends Biotechnol. 25: 455–459
  • Ramessar K, Peremerti A, Gomez-Galera S, Naqvi S, Moralejo M, Munoz P, Capell T, Christou P (2007) Biosafety and risk assessment framework for selectable marker genes in transgenic crop plants: a case of the science not supporting the politics. Transgenic Res. 16: 261–280
  • Sabharwal N, Icoz I, Saxena D, Stotzky G (2007) Release of the recombinant proteins, human serum albumin, beta-glucuronidase, glycoprotein B from human cytomegalovirus, and green fluorescent protein, in root exudates from transgenic tobacco and their effects on microbes and enzymatic activities in soil. Plant Physiol. Biochem. 45: 464–469
  • Saint-Jore-Dupas C, Faye L, Gomord V (2007) From planta to pharma with glycosylation in the toolbox. Trends Biotechnol. 25: 317–323
  • Sanvido O, Romeis J, Bigler F (2007) Ecological impacts of genetically modified crops: ten years of field research and commercial cultivation. Adv. Biochem. Eng. Biotechnol. 107: 235–278 [PubMed]
  • Saxena D, Flores S, Stotzky G (2002) Bt toxin is released in root exudates from 12 transgenic corn hybrids representing three transformation events. Soil Biol. Biochem. 34: 133–137
  • Saxena D, Stewart CN, Altosaar I, Shu Q, Stotzky G (2004) Larvicidal Cry proteins from Bacillus thuringensis are released in root exudates of transgenic B. thuringensis corn, potato and rice but not of B. thuringensis canola, cotton and tobacco. Plant Physiol. Biochem. 42: 383–387
  • Sparrow PAC, Irwin JA, Dale PJ, Twyman RM, Ma J-KC (2007) Pharma-Planta: road testing the developing regulatory guidelines for plant-made pharmaceuticals. Transgenic Res. 16: 147–161
  • Spök A (2007) Molecular farming on the rise-GMO regulators still walking a tightrope. Trends Biotechnol. 25: 74–82
  • Streatfield SJ (2007) Approaches to achieve high-level heterologous protein production in plants. Plant Biotechnol. J. 5: 2–15
  • Toubart P, Desiderio A, Salvi G, Cervone F, Daroda L, De Lorenzo G (1992) Cloning and characterization of the gene encoding the endopolygalacturonase-inhibiting protein (PGIP) of Phaseolus vulgaris L. Plant J. 2: 367–373 [PubMed]
  • Towbin H, Staehelin T, Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedures and some applications. Proc. Natl. Acad. Sci. USA 76: 4350–4353
  • Twyman RM, Schillberg S, Fischer R (2005) Transgenic plants in the biopharmaceutical market. Expert Opin. Emerg. Drugs 10: 185–218 [CrossRef] [PubMed]
  • Van Droogenbroeck B, Cao J, Stadlmann J, Altmann F, Colanesi S, Hillmer S, Robinson DG, Van Lerberge E, Terryn N, van Montagu M, Liang M, Depicker A, De Jaeger G (2007) Aberrant localization and underglycosylation of highly accumulating single-chain Fv-Fc antibodies in transgenic Arabidopsis seeds. Proc. Natl. Acad. Sci. USA 104: 1430–1435
  • van Esse HP, Thomma BPHJ, van't Klooster JW, de Wit PJGM (2006) Affinity-tags are removed from Cladosporium fulvum effector proteins expressed in the tomato leaf apoplast. J. Exp. Bot. 57: 599–608
  • Vitale A, Pedrazzini E (2005) Recombinant pharmaceuticals from plants: the plant endomembrane system as bioreactor. Mol. Interv. 5: 216-225
  • Widmer (2007) Assessing effects of transgenic crops on soil microbial communities. Adv. Biochem. Eng. Biotechnol. 107: 207–234
  • Wolt JD, Karaman S, Wang K (2007) Risk assessment for plant-made pharmaceuticals. CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources 2: 1–9